Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. Ibuprofen can increase your risk of fatal heart attack or stroke. Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. Hydrocodone is an opioid pain medication, sometimes called a narcotic. Hydrocodone and ibuprofen is a combination medicine that is used short-term to relieve severe pain. Ibuprofen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors.
Do not use this medicine just before or after heart bypass surgery coronary artery bypass graft, or CABG. These conditions can occur without warning while you are using this medicine, especially in older adults. You should not use this medicine if you are allergic to hydrocodone or ibuprofen Advil, Motrin , or if you have:. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.
These medicines may interact with hydrocodone and cause a serious condition called serotonin syndrome. If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.
Taking ibuprofen during late pregnancy may cause bleeding in the mother or the baby during delivery. Follow the directions on your prescription label and read all medication guides. Never use this medicine in larger amounts, or for longer than prescribed. Use the lowest dose that is effective in treating your condition. Tell your doctor if you feel an increased urge to take more of this medicine. Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction.
Selling or giving away opioid medicine is against the law. If you need surgery, tell the surgeon ahead of time that you are using hydrocodone and ibuprofen. Store at room temperature away from moisture and heat. Keep track of your medicine.
You should be aware if anyone is using it improperly or without a prescription. Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program.
If there is no take-back program, flush the unused medicine down the toilet. Since hydrocodone and ibuprofen is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time. Seek emergency medical attention or call the Poison Help line at Study Type :.
Interventional Clinical Trial. Actual Enrollment :. Post-operative dental pain following third molar extraction. Actual Study Start Date :. Actual Primary Completion Date :. Actual Study Completion Date :. Experimental: mg naproxen sodium with mg acetaminophen mg naproxen sodium with mg acetaminophen administered as a single dose of two naproxen sodium mg tablets and two acetaminophen mg tablets. Drug: mg naproxen sodium with mg acetaminophen mg naproxen sodium with mg acetaminophen administered as a single dose of two naproxen sodium mg tablets and two acetaminophen mg tablets Other Name: Naproxen Sodium with Acetaminophen - High Dose.
Experimental: mg naproxen sodium with mg acetaminophen mg naproxen sodium with mg acetaminophen administered as a single dose of one naproxen sodium mg tablet and two acetaminophen mg tablets and one placebo tablet.
Drug: mg naproxen sodium with mg acetaminophen mg naproxen sodium with mg acetaminophen administered as a single dose of one naproxen sodium mg tablet and two acetaminophen mg tablets and one placebo tablet Other Name: Naproxen Sodium with Acetaminophen - Low Dose. Active Comparator: mg naproxen sodium mg naproxen sodium administered as a single dose of two naproxen sodium mg tablets and two placebo tablets.
Drug: mg naproxen sodium mg naproxen sodium administered as a single dose of two naproxen sodium mg tablets and two placebo tablets Other Name: Naproxen sodium. Placebo Comparator: Placebo tablet Single dose of four placebo tablets.
Drug: Placebo tablet Single dose of four placebo tablets. March 18, Key Record Dates. Acetaminophen and naproxen work in different ways to control pain and have few overlapping side effects. Here are some tips to help you take these drugs together safely, plus warnings and other information you should know.
Both naproxen and acetaminophen help reduce fever and relieve mild to moderate pain. Examples of these types of pain include:. The drugs do different things to relieve this pain. Naproxen blocks the formation of substances that cause inflammation.
Reducing inflammation then helps to reduce pain. Instead, it reduces the sensation of pain. It works by blocking the release of substances in the brain that cause pain sensation. You can take one drug and see how it works before you add a second.
Acetaminophen, depending on the strength and type, can be taken as often as every four to six hours. Naproxen, depending on the strength and type, can be taken as often as every eight to 12 hours. That said, taking the medications alternately may help provide better pain relief. Five hours in, though, your pain may start bothering you again. In cases like this, you could take some acetaminophen to tide you over until your next dose of naproxen.
Although both drugs are generally safe for most people to use, there are certain safety considerations you should keep in mind. Make yourself aware of these considerations to help avoid misusing these drugs. Naproxen may cause allergic reactions, skin reactions, and severe stomach bleeding in some people.
Using more than recommended or using it for longer than 10 days can also increase your risk of heart attack or stroke.
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