The resulting disorders are the lipid storage diseases such as Gaucher disease Gaucher Disease Gaucher disease is a type of lysosomal storage disorder called a sphingolipidosis. It is caused by a buildup of glucocerebrosides in tissues. Children who have the infantile form usually die Types A and B are sphingolipidoses and are caused by a buildup of sphingomyelin in the tissues.
Type C is a lipidosis that is caused Low or high numbers of monocytes do not usually cause symptoms. However, people may have symptoms of the disorder that caused the change in monocyte number. Diagnosis is by blood testing complete blood count done when a person has signs or symptoms of an infection or autoimmune disorder.
Sometimes the condition is discovered by chance when a complete blood count is done during a routine physical or for the evaluation of another condition. An increased number of monocytes in the blood monocytosis occurs in response to chronic infections, in autoimmune disorders, in blood disorders, and in certain cancers. An increase in the number of macrophages in parts of the body other than in the blood such as the lungs, skin, and other organs can occur in response to infections, sarcoidosis Sarcoidosis Sarcoidosis is a disease in which abnormal collections of inflammatory cells granulomas form in many organs of the body.
Sarcoidosis usually develops in people aged 20 to 40, most often people A low number of monocytes in the blood monocytopenia can be caused by anything that decreases the overall white blood cell count see also Neutropenia Neutropenia Neutropenia is an abnormally low number of neutrophils a type of white blood cell in the blood.
Select basic ads. Create a personalised ads profile. Select personalised ads. Apply market research to generate audience insights. Measure content performance. Develop and improve products. List of Partners vendors. Monocytes are a type of white blood cell. Monocytes are formed in the bone marrow and are released into peripheral blood, where they circulate for several days. Monocytes are probably best known for their role in serving as something akin to reserve forces in the military.
Some of them may be called up if needed, to form the precursors of two other types of white blood cells: tissue macrophages and dendritic cells. But monocytes also have other roles in infection and disease, some of which have nothing to do with tissue macrophages and dendritic cells. Until recently, the main role of monocytes was considered to be sensing the environment and replenishing the pool of tissue macrophages and dendritic cells, as needed. Now it is known that subsets of monocytes have distinct markers or protein tags on the outside, and these subsets may also behave differently.
Three kinds of human monocytes are now described. The remaining 20 percent can be classified by their protein tags as non-classical monocytes and intermediate monocytes. When it comes to the different kinds of monocytes and how they function in the immune system, researchers are still working out the details, and much more is currently known about mouse monocytes than human monocytes.
It is not yet certain in humans, however, what proportion of monocytes are mobile enough to go in and out of tissues, and evidence suggests there may be kinds of monocytes that can engulf and digest, or phagocytize, invaders but without actively promoting inflammation. A good number of human monocytes are believed to migrate into tissues throughout your body where they may reside or give rise to macrophages that perform essential functions to fight infection and clean up dead cells.
In this way, the spleen can be an active site for the innate immune system. Innate immunity refers to the immunity you are born with, not the more targeted immunity you might develop after, say, a vaccine or after recovering from an infectious illness. The innate immune system works through different mechanisms, including phagocytosis and inflammation.
Macrophages can engage in phagocytosis, a process by which they engulf and destroy debris and invaders. They can also "retire" any old, worn-out red blood cells in this way. For example, a study found that a high-monocyte-to-low-lymphocyte ratio can help identify disease activity in people with ulcerative colitis.
Treatment of elevated monocytes depends on the cause. Your doctor may have to do more tests to determine the underlying cause. Generally, treatment may include the following:. When it comes to white blood cells, you want to keep them all within the healthy range. Regular exercise is an important component to overall good health and maintaining the right blood counts.
Since monocytes respond to inflammation, an anti-inflammatory diet might be beneficial. Anti-inflammatory foods include:. The Mediterranean diet is a good example of an anti-inflammatory diet.
It includes a lot of fresh vegetables, fruit, nuts, seeds, fish, olive oil, and whole grains. The white blood cell count is complicated. If you think your monocyte level is too high, talk to your doctor about why that is, whether you need treatment, and if lifestyle changes may be helpful.
Monocytes, along with other types of white blood cells, are a vital part of your immune system. They help protect you against infection and illness.
If your monocytes are higher than they should be, your doctor will work with you to find the cause and start any treatments that may be necessary.
White blood cells, or WBCs, are an important part of your immune system. If the body has white blood cells, then the normal absolute monocytes range is between 80 and Having an absolute monocytes count that is higher or lower than typical is not dangerous in itself, but it can indicate that the person needs to be examined further.
A high monocyte count or high monocyte can indicate other medical conditions. An infection by a bacteria, virus or fungus can cause an increase in monocyte levels. This is because the body creates more monocytes to fight the invader. An absolute monocytes high can also be a response to stress, chronic infections or autoimmune disorders.
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