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These people are most often not affected with the condition. However, they can pass the abnormal gene to their children. If you are born to parents who both carry the same autosomal recessive gene, you have a 1 in 4 chance of inheriting the abnormal gene from both parents and developing the disease. This would make you a carrier. In other words, for a child born to a couple who both carry the gene but do not have signs of disease , the expected outcome for each pregnancy is:. Note: These outcomes do not mean that the children will definitely be carriers or be severely affected.
Clinical genomics. Textbook of Family Medicine. Sickle cells live only for about 15 days. Normal hemoglobin cells can live up to days. Sickle cells risk being destroyed by the spleen because of their shape and stiffness.
The spleen helps filter the blood of infections. Sickle cells get "stuck" in this filter and die. Due to the decreased number of hemoglobin cells circulating in the body, a person with sickle cell is chronically anemic. The spleen also suffers damage from the sickle cells, which block the healthy oxygen-carrying cells.
After repeated blockages, the spleen is very small and does not work properly. Without a functioning spleen, these people are more at risk for infections. Infants and young children are at risk for life-threatening infections. Treatment includes prompt emergency care for fevers and infections, appropriate vaccinations, penicillin, and management of anemia.
Tay-Sachs disease is a fatal disorder in children usually by age 5 that causes a progressive degeneration of the central nervous system. Our Housecall e-newsletter will keep you up-to-date on the latest health information.
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