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Guidot, D. Inhaled NO prevents IL-1 induced neutrophil accumulation and associated acute edema in isolated rat lungs. Guo, K. Nitric oxide-induced down-regulation of Cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells.
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Spencer, J. Base modification and strand breakage in isolated calf thymus DNA and in DNA from human skin epidermal keratinocytes exposed to peroxynitrite or 3-morpholinosydnonimine. Nitric oxide is now recognized as playing an important role in the regulation of diverse physiological processes. However, the pharmacological properties of inhaled nitric oxide are not easy to separate from its toxicological effects.
For example, the intended effect of inhaled nitric oxide, vasodilation in the lung, is mediated, in part, by increased cellular cyclic GMP cGMP. However, increased cGMP can also interfere with normal cellular proliferation. Blood tests may be needed to check for unwanted effects. Your baby's doctor also needs to monitor your baby's breathing, oxygen levels, and other vital signs while receiving this medicine.
Stopping this medicine suddenly may increase your baby's risk to have rebound pulmonary hypertension syndrome. Symptoms include: bluish lips or skin, slow heartbeat, lightheadedness, dizziness, or fainting, or decreased cardiac output. This medicine may cause a rare, but serious blood problem called methemoglobinemia.
Your baby's doctor will measure how much methemoglobin is in your baby's blood while receiving this medicine. Do not take other medicines unless they have been discussed with your doctor.
This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal or vitamin supplements. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects may occur that usually do not need medical attention.
These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. Other side effects not listed may also occur in some patients.
If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.
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